BDBM320165 3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Diastereoisomers::US10174016, Example 332::US10202369, Example 333

SMILES C[C@@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=FUZHKJYNGBDBHI-UHFFFAOYSA-N

Data  15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 320165   

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/16/2019
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TargetP2X purinoceptor 2(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 174nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/16/2019
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TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/16/2019
Entry Details
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TargetP2X purinoceptor 2(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 122nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/16/2019
Entry Details
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TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetP2X purinoceptor 2(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 174nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/15/2019
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TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 174nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 122nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetCytochrome P450 1A2(Human)
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US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Human liver microsomes (pooled, >30 male and female donors) were incubated with individual CYP isoform-selective standard probes (phenacetin for CYP1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
9/2/2019
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TargetCytochrome P450 2C8(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Human liver microsomes (pooled, >30 male and female donors) were incubated with individual CYP isoform-selective standard probes (phenacetin for CYP1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2019
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TargetCytochrome P450 2C9(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 1.98E+4nMAssay Description:Human liver microsomes (pooled, >30 male and female donors) were incubated with individual CYP isoform-selective standard probes (phenacetin for CYP1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetCytochrome P450 2D6(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Human liver microsomes (pooled, >30 male and female donors) were incubated with individual CYP isoform-selective standard probes (phenacetin for CYP1...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetCytochrome P450 3A4(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320165(US10174016, Example 332 | 3-[(3-methyltetrahydrofu...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Human liver microsomes (pooled, >30 male and female donors) were incubated with individual CYP isoform-selective standard probes (phenacetin for CYP1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2019
Entry Details
Copy Entry DOIGo to US Patent

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