BDBM320458 US10174035, Compound 5::{4-[cis-2,6-Dimethylmorpholin-4-yl]piperidin-1-yl}[2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-9H-purin-8-yl]methanone

SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1

InChI Key InChIKey=XYCUAWVHWOMPQA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320458   

LigandPNGBDBM320458(US10174035, Compound 5 | {4-[cis-2,6-Dimethylmorph...)
Affinity DataIC50: 11nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM320458(US10174035, Compound 5 | {4-[cis-2,6-Dimethylmorph...)
Affinity DataIC50: 1.00E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM320458(US10174035, Compound 5 | {4-[cis-2,6-Dimethylmorph...)
Affinity DataIC50: 1.18E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM320458(US10174035, Compound 5 | {4-[cis-2,6-Dimethylmorph...)
Affinity DataIC50: 11nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent