BDBM320461 2-(4-{[2-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-9H-purin-8-yl]carbonyl}piperazin-1-yl)-2-methylpropanamide::US10174035, Compound 8

SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O

InChI Key InChIKey=XCVHLPGIJCEADG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 320461   

LigandPNGBDBM320461(US10174035, Compound 8 | 2-(4-{[2-(1,3-Dimethyl-1H...)
Affinity DataIC50: 10nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM320461(US10174035, Compound 8 | 2-(4-{[2-(1,3-Dimethyl-1H...)
Affinity DataIC50: 6.48E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM320461(US10174035, Compound 8 | 2-(4-{[2-(1,3-Dimethyl-1H...)
Affinity DataIC50: 1.00E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM320461(US10174035, Compound 8 | 2-(4-{[2-(1,3-Dimethyl-1H...)
Affinity DataIC50: 6.54E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM320461(US10174035, Compound 8 | 2-(4-{[2-(1,3-Dimethyl-1H...)
Affinity DataIC50: 10nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent