BDBM320521 9-Methyl-2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-N-[3-(morpholin-4-yl)propyl]-9H-purine-8-carboxamide::US10174035, Compound 67

SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc(C(=O)NCCCN3CCOCC3)n(C)c2n1

InChI Key InChIKey=WGEOWOQUQGGPMC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 320521   

LigandPNGBDBM320521(US10174035, Compound 67 | 9-Methyl-2-(1-methyl-1H-...)
Affinity DataIC50: 11nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM320521(US10174035, Compound 67 | 9-Methyl-2-(1-methyl-1H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM320521(US10174035, Compound 67 | 9-Methyl-2-(1-methyl-1H-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM320521(US10174035, Compound 67 | 9-Methyl-2-(1-methyl-1H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM320521(US10174035, Compound 67 | 9-Methyl-2-(1-methyl-1H-...)
Affinity DataIC50: 11nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent