BDBM320642 (S)-3-(Fluoromethyl)-6-hydroxy-1- (1-(4- (pentafluorolhio)phenyl)ethyl)-1H- pyrazolo[3,4-d]pyrimidin-4(5H)- one::US10174037, Example 50

SMILES C[C@@H](c1ccc(cc1)C(F)(F)F)n1nc(CF)c2c1nc(O)[nH]c2=O

InChI Key InChIKey=IKXUQDQGFGOUFF-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 320642   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320642((S)-3-(Fluoromethyl)-6-hydroxy-1- (1-(4- (pentaflu...)
Affinity DataKi:  6.80nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320642((S)-3-(Fluoromethyl)-6-hydroxy-1- (1-(4- (pentaflu...)
Affinity DataKi:  7nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM320642((S)-3-(Fluoromethyl)-6-hydroxy-1- (1-(4- (pentaflu...)
Affinity DataIC50: 899nMAssay Description:Inhibition of human GST-tagged PDE9A2 expressed in insect cells using FAM-labeled cGMP as substrate incubated for 60 mins measured after 1 hr by IMAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed