BDBM320991 4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]tetrahydrofuran-2-yl]-5-[2-(2-ethoxy-6-fluoro-phenyl)ethynyl]pyrrolo[2,3-d]pyrimidine::US10174040, Example 55::US9963456, Example 55

SMILES CCOc1cccc(F)c1C#Cc1cn([C@@H]2O[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12

InChI Key InChIKey=TZTRUHFXPVXWRD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 320991   

TargetNEDD8-conjugating enzyme UBE2F(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 1.00E+3nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 1.00E+3nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 0.955nMAssay Description:Inhibition of recombinant human APPBP1/UBA3 expressed in Escherichia coli assessed as Ub/Ubl thioester transferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetUbiquitin-like modifier-activating enzyme 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 449nMAssay Description:Inhibition of recombinant C-terminal His-tagged human full length UAE1 expressed in Escherichia coli BL21 (lambdaDE3) assessed as reduction in transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSUMO-activating enzyme subunit 1/2(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of recombinant human SAE1/UBA2 expressed in Escherichia coli assessed as reduction in transfer of UMO1 to UBE2I enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: 730nMAssay Description:Inhibition of human erythrocyte carbonic anhydrase 2 using 4-Nitrophenyl acetate as substrate preincubated for 15 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed