BDBM323779 4-{[(6-Chloro-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid::US10189788, Example 59

SMILES Cc1c(nc2ccc(Cl)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1

InChI Key InChIKey=XSVDBJSFVAZDBV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 323779   

TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323779(4-{[(6-Chloro-3-methyl-2-phenylquinolin-4-yl)carbo...)
Affinity DataIC50: 203nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM323779(4-{[(6-Chloro-3-methyl-2-phenylquinolin-4-yl)carbo...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323779(4-{[(6-Chloro-3-methyl-2-phenylquinolin-4-yl)carbo...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed