BDBM32530 arylsulfonylpiperazine, 2

SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccccc1

InChI Key InChIKey=RNOYTDIICXQMFU-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 32530   

LigandPNGBDBM32530(arylsulfonylpiperazine, 2)
Affinity DataIC50: 45nM EC50:  724nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2009
Entry Details Article
PubMed
LigandPNGBDBM32530(arylsulfonylpiperazine, 2)
Affinity DataIC50: 122nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM32530(arylsulfonylpiperazine, 2)
Affinity DataIC50: 45nMAssay Description:Inhibition of human 11betaHSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
LigandPNGBDBM32530(arylsulfonylpiperazine, 2)
Affinity DataIC50: 122nMAssay Description:Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM32530(arylsulfonylpiperazine, 2)
Affinity DataIC50: 61nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed