BDBM325772 (rac)-2-[4-[2-Fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl]-1-[(2S)-2-methylpyrrolidin-1-yl]ethanone::US9636339, 22

SMILES C[C@H]1CCCN1C(=O)CC1CCc2c1cncc2-c1ccc(cc1F)C(F)(F)F

InChI Key InChIKey=ITOYCCIMGZVFSY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 325772   

TargetCytochrome P450 11B1, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM325772((rac)-2-[4-[2-Fluoro-4-(trifluoromethyl)phenyl]-6,...)
Affinity DataEC50:  278nMAssay Description:G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM325772((rac)-2-[4-[2-Fluoro-4-(trifluoromethyl)phenyl]-6,...)
Affinity DataEC50:  6nMAssay Description:G-402 cells expressing CYP11 constructs were established as described above and maintained in McCoy's 5a Medium Modified, ATCC Catalog No. 30-200...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent