BDBM326287 (R)-4-((1- cyclobutylethyl)amino)- 6-(2-fluoro-5- methylphenyl)-5-(4- (trifluoromethyl) benzyl)-5H-pyrrolo [3, 2-d] pyrimidine-2- carboxylic acid::US9637493, 1.1

SMILES C[C@@H](Nc1nc(nc2cc(-c3cc(C)ccc3F)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1

InChI Key InChIKey=SSLMPUKAUBJZCY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326287   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326287((R)-4-((1- cyclobutylethyl)amino)- 6-(2-fluoro-5- ...)
Affinity DataIC50: 62nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent