BDBM326302 4-{[(1R)-1- cyclobutylethyl]amino}- 5-[2-methoxy-4- (trifluoromethoxy) benzyl]-6-(3- methylphenyl)-5H- pyrrolo[3,2- d]pyrimidine-2- carboxylic acid::US9637493, 2.5

SMILES COc1cc(OC(F)(F)F)ccc1Cn1c(cc2nc(nc(N[C@H](C)C3CCC3)c12)C(O)=O)-c1cccc(C)c1

InChI Key InChIKey=YQPIKNVBYYFAJY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326302   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326302(4-{[(1R)-1- cyclobutylethyl]amino}- 5-[2-methoxy-4...)
Affinity DataIC50: 4.37E+3nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
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