BDBM326303 4-{[(1R)-1- cyclobutylethyl] amino}-5-[4- (difluoromethoxy) benzyl]-6-(3- methylphenyl)-5H- pyrrolo[3,2- d]pyrimidine-2- carboxylic acid::US9637493, 2.6

SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(OC(F)F)cc3)c12)C(O)=O)C1CCC1

InChI Key InChIKey=LJNLTTIPTKLOAW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326303   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326303(4-{[(1R)-1- cyclobutylethyl] amino}-5-[4- (difluor...)
Affinity DataIC50: 1.78E+3nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent