BDBM326305 4-{[(1R)-1- cyclobutylethyl] amino}-5-(4- methoxybenzyl)-6- (3-methylphenyl)-5H- pyrrolo[3,2- d]pyrimidine-2- carboxylic acid::US9637493, 2.8

SMILES COc1ccc(Cn2c(cc3nc(nc(N[C@H](C)C4CCC4)c23)C(O)=O)-c2cccc(C)c2)cc1

InChI Key InChIKey=BIIHFRXIZRHHJC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326305   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326305(4-{[(1R)-1- cyclobutylethyl] amino}-5-(4- methoxyb...)
Affinity DataIC50: 6.19E+3nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent