BDBM326311 4-{[(1R)-1- cyclobutylethyl]amino}- 5-(3-fluoro-4- methylbenzyl)-6-(3- methylphenyl)-5H- pyrrolo[3,2- d]pyrimidine-2- carboxylic acid::US9637493, 3.6

SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(C)c(F)c3)c12)C(O)=O)C1CCC1

InChI Key InChIKey=PQPUXZGSEPZFLZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326311   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326311(4-{[(1R)-1- cyclobutylethyl]amino}- 5-(3-fluoro-4-...)
Affinity DataIC50: 124nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent