BDBM326312 4-(3-chlorophenyl)-5- [(trans-4- methylcyclohexyl)methyl]- 5H-pyrrolo[3,2- d]pyrimidine-2-carboxylic acid::US9637493, 4.1

SMILES C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cccc(Cl)c4)c23)C(O)=O)CC1

InChI Key InChIKey=PELPGAUFEHLQMQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326312   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326312(4-(3-chlorophenyl)-5- [(trans-4- methylcyclohexyl)...)
Affinity DataIC50: 294nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent