BDBM326324 3-[4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcyclohexyl)methyl]- 7-(2-methylpropyl)-5H- pyrrolo[3,2-d]pyrimidin-2- yl]-1,2,4-oxadiazol-5(4H)- one::US9637493, 5.8

SMILES CC(C)Cc1cn(C[C@H]2CC[C@H](C)CC2)c2c(nc(nc12)-c1noc(=O)[nH]1)-c1cncc(Cl)c1

InChI Key InChIKey=PBWNVJSHYSJKQB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326324   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326324(3-[4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Affinity DataIC50: 35nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
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Date in BDB:
5/29/2019
Entry Details
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