BDBM326329 3-{4-(5-chloropyridin-3- yl)-6-[fluoro(2- fluorophenyl)methyl]-5- [(trans-4- methylcyclohexyl)methyl]- 5H-pyrrolo[3,2- d]pyrimidin-2-yl}-1,2,4- oxadiazol-5(4H)-one (racemate)::US9637493, 8.2

SMILES C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)C(F)c2ccccc2F)CC1

InChI Key InChIKey=MDDWTEBQIZRNHB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326329   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326329(3-{4-(5-chloropyridin-3- yl)-6-[fluoro(2- fluoroph...)
Affinity DataIC50: 2nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent