BDBM326330 4-(5-chloropyridin-3-yl)-6- [(1R or S)-1-fluoro-1-(3- fluoropyridin-2-yl)ethyl]-5- [(trans-4- methylcyclohexyl)methyl]- 5H-pyrrolo[3,2- d]pyrimidine-2-carboxylic acid (Enantiomer 1)::US9637493, 8.3::US9637493, 8.4

SMILES C[C@H]1CC[C@H](Cn2c(cc3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)C(C)(F)c2ncccc2F)CC1

InChI Key InChIKey=AMGHPQMDOLZNKZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 326330   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326330(US9637493, 8.3 | 4-(5-chloropyridin-3-yl)-6- [(1R ...)
Affinity DataIC50: 8nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326330(US9637493, 8.3 | 4-(5-chloropyridin-3-yl)-6- [(1R ...)
Affinity DataIC50: 1nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
Go to US Patent