BDBM328133 N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2,4- difluorobenzoyl) piperidine-1- carbonyl)picolinamide::US10377742, Compound 271::US9663496, Compound 271

SMILES Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1

InChI Key InChIKey=XRDMDDSSWUSOAX-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 328133   

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM328133(US9663496, Compound 271 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM328133(US9663496, Compound 271 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM328133(US9663496, Compound 271 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM328133(US9663496, Compound 271 | N-(1-(4- cyanobenzyl)pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed