BDBM331894 (R)-1-(4-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl)piperazin-1-yl)-3-methoxypropan-2-ol::US10189859, Compound 96

SMILES COC[C@H](O)CN1CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=TVDOGXZPNZJBCI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331894   

TargetSodium channel protein type 9 subunit alpha(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM331894(US10189859, Compound 96 | (R)-1-(4-(5-amino-6-(2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM331894(US10189859, Compound 96 | (R)-1-(4-(5-amino-6-(2,3...)
Affinity DataIC50: 2.00E+5nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent