BDBM331928 (2S)-1-(6-(5-amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl)-1,6-diazaspiro[3.5]nonan-1-yl)-3-methoxypropan-2-ol::US10189859, Compound 161

SMILES COC[C@@H](O)CN1CCC11CCCN(C1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=DGWCLSOPVZFHPD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331928   

TargetSodium channel protein type 9 subunit alpha(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM331928(US10189859, Compound 161 | (2S)-1-(6-(5-amino-6-(2...)
Affinity DataIC50: 1.47E+5nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM331928(US10189859, Compound 161 | (2S)-1-(6-(5-amino-6-(2...)
Affinity DataIC50: 5.14E+4nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent