BDBM331929 (2S)-1-{4-[5-Amino-6-(2,3-dichlorophenyl)-1,2,4-triazin-3-yl]piperazin-1-yl}-3-(cyclobutyloxy)propan-2-ol::US10189859, Compound 84

SMILES Nc1nc(nnc1-c1cccc(Cl)c1Cl)N1CCN(C[C@H](O)COC2CCC2)CC1

InChI Key InChIKey=SOCABZFEVHJTST-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331929   

TargetSodium channel protein type 9 subunit alpha(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM331929(US10189859, Compound 84 | (2S)-1-{4-[5-Amino-6-(2,...)
Affinity DataIC50: 1.92E+5nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Nektar Therapeutics

US Patent
LigandPNGBDBM331929(US10189859, Compound 84 | (2S)-1-{4-[5-Amino-6-(2,...)
Affinity DataIC50: 5.00E+4nMAssay Description:The potencies of the compounds provided herein to block specific Na+ channels was measured using automated patch clamp electrophysiologically of Nav1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent