BDBM332419 4-{1-[(2-bromo- 3-methyl- phenyl) carbonyl]-1H- indazol-3-yl}- 3-fluoro- benzoic acid::US10196354, Example 1O::US9745265, 1O

SMILES Cc1cccc(C(=O)n2nc(-c3ccc(cc3F)C(O)=O)c3ccccc23)c1Br

InChI Key InChIKey=VQYAVXSWJIEBDY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332419   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332419(US10196354, Example 1O | 4-{1-[(2-bromo- 3-methyl-...)
Affinity DataIC50: 54nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332419(US10196354, Example 1O | 4-{1-[(2-bromo- 3-methyl-...)
Affinity DataIC50: 54nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent