BDBM332420 4-[1-(2,3- dihydro-1H- inden-4- ylcarbonyl)-1H- indazol-3-yl]-3- fluorobenzoic acid::US10196354, Example 1P::US9745265, 1P

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3cccc4CCCc34)c3ccccc23)c(F)c1

InChI Key InChIKey=ZQSOJGWWQMLPEG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332420   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332420(US10196354, Example 1P | 4-[1-(2,3- dihydro-1H- in...)
Affinity DataIC50: 58nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332420(US10196354, Example 1P | 4-[1-(2,3- dihydro-1H- in...)
Affinity DataIC50: 58nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent