BDBM332426 4-(1-(2-chloro- 6-vinyl- benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1V::US9745265, 1V

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C=C)c3cccnc23)c(F)c1

InChI Key InChIKey=HYDRWUOWOHAYOO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332426   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332426(US10196354, Example 1V | 4-(1-(2-chloro- 6-vinyl- ...)
Affinity DataIC50: 16nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332426(US10196354, Example 1V | 4-(1-(2-chloro- 6-vinyl- ...)
Affinity DataIC50: 16nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent