BDBM332429 4-(1-(2- (dimethyl- amino)-6- methyl- benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1Y::US9745265, 1Y

SMILES CN(C)c1cccc(C)c1C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12

InChI Key InChIKey=ULWLHAACQVHNPR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332429   

TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332429(US10196354, Example 1Y | 4-(1-(2- (dimethyl- amino...)
Affinity DataIC50: 40nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332429(US10196354, Example 1Y | 4-(1-(2- (dimethyl- amino...)
Affinity DataIC50: 40nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent