BDBM332443 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(oxetan- 3-ylamino)-1H- indazol-3-yl)-3- fluorobenzoic acid::US10196354, Example 4F::US9745265, 4F

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(NC4COC4)ccc23)c(F)c1

InChI Key InChIKey=ARZXKYMGJALLBA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332443   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332443(US10196354, Example 4F | 4-(1-(2-chloro-6- (triflu...)
Affinity DataIC50: 23nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332443(US10196354, Example 4F | 4-(1-(2-chloro-6- (triflu...)
Affinity DataIC50: 23nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent