BDBM332524 4-(1-(2-chloro-6- (trifluoromethyl)benzoyl)-6- (3-methoxy-azetidine-1- carbonyl)-1H-indol-3-yl)-3- fluorobenzoic acid::US10196354, Example 36B::US9745265, 36B

SMILES COC1CN(C1)C(=O)c1ccc2c(cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O

InChI Key InChIKey=QWGWQRAYHKIEDH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332524   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332524(US10196354, Example 36B | 4-(1-(2-chloro-6- (trifl...)
Affinity DataIC50: 1nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332524(US10196354, Example 36B | 4-(1-(2-chloro-6- (trifl...)
Affinity DataIC50: 1nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent