BDBM332763 Cis-(chiral)-N-[2-[5-(1,4- Dimethyl-1H-imidazol-5-yl)- 4H-1,2,4-triazol-3- yl]tetrahydro-2H-pyran-4- yl]-N-methyl-3- (trifluoromethoxy)benzamide, Isomer 1::US10196385, Example 2

SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=QNCLPVUZVLXOPW-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332763   

TargetProbable G-protein coupled receptor 142(Human)
Lilly China Research and Development Center (Lcrdc)

Curated by ChEMBL
LigandPNGBDBM332763(US10196385, Example 2 | Cis-(chiral)-N-[2-[5-(1,4-...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 142(Human)
Lilly China Research and Development Center (Lcrdc)

Curated by ChEMBL
LigandPNGBDBM332763(US10196385, Example 2 | Cis-(chiral)-N-[2-[5-(1,4-...)
Affinity DataEC50:  30.1nMAssay Description:HEK293 cells expressing human GPR142 are maintained in DMEM supplemented with 10% FBS and 800 μg/ml G418 (Geneticin) at 37° C. and 5% CO2. The c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent