BDBM332942 US10196390, Compound I-231::US10336752, Compound 9::US11040967, Compound 9

SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cc2)C(=O)N2CCOCC2)c2C(=O)NCc2n1

InChI Key InChIKey=XDTKWAGKBLDFOE-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 332942   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataIC50: 134nMAssay Description:Compounds were serially diluted in DMSO then further diluted in 1x kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataIC50: 134nMAssay Description:Compounds were serially diluted in DMSO then further diluted in 1× kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Jak2 in human PBMC assessed as inhibition of GM-CSF-stimulated phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Jak1/Jak3 in human PBMC assessed as inhibition of IL2-stimulated phosphorylation of STAT5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataKi: <10nMAssay Description:The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332942(US10196390, Compound I-231 | US10336752, Compound ...)
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
Go to US Patent