BDBM332959 US10196390, Compound I-248

SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2CCOCC2=O)c2C(=O)NCc2n1

InChI Key InChIKey=MBDFURBNMPAMJT-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 332959   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332959(US10196390, Compound I-248)
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2 in human PBMC assessed as inhibition of IL-12-stimulated phosphorylation of STAT4 measured by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332959(US10196390, Compound I-248)
Affinity DataKi:  0.340nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) measured in presence of 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM332959(US10196390, Compound I-248)
Affinity DataKi: <10nMAssay Description:The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM332959(US10196390, Compound I-248)
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details
Go to US Patent