BDBM333802 1-(3-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)-3- (3-ethyl1- phenyl-1H- pyrazol-5-yl) urea::US9730937, Example 352

SMILES CCc1cc(NC(=O)Nc2cccc(Oc3ncnc4cc(OC)c(OC)cc34)c2)n(n1)-c1ccccc1

InChI Key InChIKey=JMZSQRFDAJTNEQ-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333802   

TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333802(1-(3-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333802(1-(3-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM333802(1-(3-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)...)
Affinity DataKd: <250nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent