BDBM333925 9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(tetrahydro-2H- pyran-4-ylcarbonyl)pyrrolidin- 3-yl]oxy}-9H-purine::US9730940, Compound 2-26

SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)C3CCOCC3)ncnc12)-c1cnc(C)nc1

InChI Key InChIKey=FQCPBYZODMZDKG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 333925   

LigandPNGBDBM333925(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(te...)
Affinity DataIC50: 8.5nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

LigandPNGBDBM333925(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(te...)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM333925(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(te...)
Affinity DataIC50: 390nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed