BDBM334009 6-({(3S)-1-[(1R,2S,4S)- bicyclo[2.2.1]hept-2- ylcarbonyl]pyrrolidin-3-yl}oxy)- 9-ethyl-8-(2-methylpyrimidin-5- yl)-9H-purine::US9730940, Compound 2-110

SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)[C@H]3C[C@H]4CC[C@@H]3C4)ncnc12)-c1cnc(C)nc1

InChI Key InChIKey=HBCPQWYVOADKMI-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 334009   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck Sharp & Dohme

US Patent

LigandBDBM334009(6-({(3S)-1-[(1R,2S,4S)- bicyclo[2.2.1]hept-2- ylca...)Copy SMILESCopy InChI

Affinity DataIC50: 1.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL