BDBM334128 (R or S )-6-{[5- (cyclopropylcarbonyl)-5- azaspiro[2.4]hept-7-yl]oxy}-9- ethyl-8-(2-methylpyrimidin-5- yl)-9H-purine::US9730940, Compound 3-63::US9730940, Compound 3-64

SMILES CCn1c(nc2c(OC3CN(CC33CC3)C(=O)C3CC3)ncnc12)-c1cnc(C)nc1

InChI Key InChIKey=ACNJOMWVEWCPGQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 334128   

LigandPNGBDBM334128((R or S )-6-{[5- (cyclopropylcarbonyl)-5- azaspir...)
Affinity DataIC50: 380nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM334128((R or S )-6-{[5- (cyclopropylcarbonyl)-5- azaspir...)
Affinity DataIC50: 1.30nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent