BDBM334927 US11040966, Example 5.19::US9732075, Example 5.19::US9914721, Ex. 2::[(S)-2-(5-Bromo-7-methyl-1H-benzoimidazol-2-yl)-2-methyl-pyrrolidin-1-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone

SMILES Cc1ccc(c(c1)C(=O)N1CCC[C@@]1(C)c1nc2cc(Br)cc(C)c2[nH]1)-n1nccn1

InChI Key InChIKey=XSONELHLKWDPKV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 334927   

TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334927(US9732075, Example 5.19 | [(S)-2-(5-Bromo-7-methyl...)
Affinity DataIC50: 9nMAssay Description:Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334927(US9732075, Example 5.19 | [(S)-2-(5-Bromo-7-methyl...)
Affinity DataIC50: 9nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334927(US9732075, Example 5.19 | [(S)-2-(5-Bromo-7-methyl...)
Affinity DataIC50: 20nMAssay Description:Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334927(US9732075, Example 5.19 | [(S)-2-(5-Bromo-7-methyl...)
Affinity DataIC50: 20nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent