BDBM336536 US9745283, Example 9

SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(CC=C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC

InChI Key InChIKey=KRCXQWNNHBDOFE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336536   

TargetHepatocyte growth factor receptor(Human)
Ignyta

US Patent
LigandPNGBDBM336536(US9745283, Example 9)
Affinity DataIC50: 10nMAssay Description:The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Ignyta

US Patent
LigandPNGBDBM336536(US9745283, Example 9)
Affinity DataIC50: 10nMAssay Description:The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent