BDBM336545 US9745283, Example 14

SMILES [#6]-[#8]-c1cc2nccc(-[#8]-c3ccc(-[#7]-[#6](=O)-c4cn(-[#6]\[#6]=[#6](\F)F)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1-[#8]-[#6]

InChI Key InChIKey=DSKWGNSRSNIYPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336545   

TargetHepatocyte growth factor receptor(Human)
Ignyta

US Patent
LigandPNGBDBM336545(US9745283, Example 14)
Affinity DataIC50: 10nMAssay Description:The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Ignyta

US Patent
LigandPNGBDBM336545(US9745283, Example 14)
Affinity DataIC50: 10nMAssay Description:The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent