BDBM336750 4-ethoxy-2- {[(3R,6R)-6- methyl-1-{[2- (2H-tetrazol-2- yl)phenyl] carbonyl} piperidin-3- yl]oxy}pyridine::US9745284, 8

SMILES CCOc1ccnc(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2-n2ncnn2)c1

InChI Key InChIKey=BAGRQLSLJGYRJT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336750   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336750(4-ethoxy-2- {[(3R,6R)-6- methyl-1-{[2- (2H-tetrazo...)
Affinity DataIC50: 35.4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336750(4-ethoxy-2- {[(3R,6R)-6- methyl-1-{[2- (2H-tetrazo...)
Affinity DataIC50: 2.01E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent