BDBM336753 4-methoxy-2- {[(3R,6R)-6- methyl-1-{[2- (trifluoromethyl) phenyl]carbonyl} piperidin-3-yl] oxy}pyridine::US9745284, 13

SMILES COc1ccnc(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2C(F)(F)F)c1

InChI Key InChIKey=ODQYMONASKUWRZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336753   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336753(4-methoxy-2- {[(3R,6R)-6- methyl-1-{[2- (trifluoro...)
Affinity DataIC50: 56.2nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336753(4-methoxy-2- {[(3R,6R)-6- methyl-1-{[2- (trifluoro...)
Affinity DataIC50: 1.76E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent