BDBM336776 4-(2,2-difluoroethoxy)-2- {[(3R,6R)-6-methyl-1-{[2- (5-methyl-1,2,4-oxadiazol-3- yl)phenyl]carbonyl}piperidin- 3-yl]oxy}pyridine::US9745284, 38

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1noc(C)n1)Oc1cc(OCC(F)F)ccn1

InChI Key InChIKey=OMBSEAHYCKDTMZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336776   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336776(4-(2,2-difluoroethoxy)-2- {[(3R,6R)-6-methyl-1-{[2...)
Affinity DataIC50: 56nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336776(4-(2,2-difluoroethoxy)-2- {[(3R,6R)-6-methyl-1-{[2...)
Affinity DataIC50: 2.50E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent