BDBM336781 2-(2-{[(2R,5R)-5-{[4-(2,2- difluoroethoxy)pyridin-2- yl]oxy}-2- methylpiperidin-1- yl]carbonyl}phenyl) pyrimidine::US9745284, 45

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ncccn1)Oc1cc(OCC(F)F)ccn1

InChI Key InChIKey=OGUABBYQKDOWFM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336781   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336781(2-(2-{[(2R,5R)-5-{[4-(2,2- difluoroethoxy)pyridin-...)
Affinity DataIC50: 33nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336781(2-(2-{[(2R,5R)-5-{[4-(2,2- difluoroethoxy)pyridin-...)
Affinity DataIC50: 2.94E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent