BDBM336791 4-(difluoromethoxy)- 2-{[(3R,6R)- 6-methyl-1- {[4-(2H-1,2,3- triazol-2-yl) thiophen-3- yl]carbonyl} piperidin- 3-yl]oxy}pyridine::US9745284, 55

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)Oc1cc(OC(F)F)ccn1

InChI Key InChIKey=CLCUVQHMSAJFFH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336791   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336791(4-(difluoromethoxy)- 2-{[(3R,6R)- 6-methyl-1- {[4-...)
Affinity DataIC50: 13nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336791(4-(difluoromethoxy)- 2-{[(3R,6R)- 6-methyl-1- {[4-...)
Affinity DataIC50: 1.76E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent