BDBM336794 ((2R,5R)-5-((4-Methoxypyridin-2-yl)oxy)-2-methylpiperidin-1-yl)(2-(pyrimidin-2-yl)thiophen-3-yl)methanone::US9745284, 58

SMILES COc1ccnc(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccsc2-c2ncccn2)c1

InChI Key InChIKey=IHDPOVVYCVYVSA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336794   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336794(((2R,5R)-5-((4-Methoxypyridin-2-yl)oxy)-2-methylpi...)
Affinity DataIC50: 21nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM336794(((2R,5R)-5-((4-Methoxypyridin-2-yl)oxy)-2-methylpi...)
Affinity DataIC50: 1.11E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent