BDBM339987 (R)-5-((2-Amino-3-methoxypropyl)amino)-3-(1H-indol-2-yl)pyrazine-2-carboxamide::US9775839, 8.1

SMILES COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1

InChI Key InChIKey=IDMVGKAHNPRBPB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339987   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM339987((R)-5-((2-Amino-3-methoxypropyl)amino)-3-(1H-indol...)
Affinity DataIC50: 6.40nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
Go to US Patent