BDBM339988 5-{[(3R,4R)-4-amino-1,1- dioxidotetrahydro-2H- thiopyran-3-yl]amino}-3- (1H-indol-2-yl)pyrazine-2- carboxamide::US9775839, 8.2

SMILES N[C@@H]1CCS(=O)(=O)C[C@@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1

InChI Key InChIKey=VDEVHXXEHRYPAG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339988   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM339988(5-{[(3R,4R)-4-amino-1,1- dioxidotetrahydro-2H- thi...)
Affinity DataIC50: 124nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
Go to US Patent