BDBM340696 1,1,1,3,3,3-hexafluoro-2-(4-(1-((4-fluorophenyl)sulfonyl)cyclopentyl)phenyl)propan-2-amine::US9771320, Example 9

SMILES NC(c1ccc(cc1)C1(CCCC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=DLEUANUZDIUIBV-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 340696   

TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM340696(US9771320, Example 9 | 1,1,1,3,3,3-hexafluoro-2-(4...)
Affinity DataIC50: 89nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2019
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM340696(US9771320, Example 9 | 1,1,1,3,3,3-hexafluoro-2-(4...)
Affinity DataEC50:  275nMAssay Description:Transactivation of PXR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM340696(US9771320, Example 9 | 1,1,1,3,3,3-hexafluoro-2-(4...)
Affinity DataEC50:  888nMAssay Description:Inverse agonist activity at GAL4-fused RORgammat LBD (267 to 516 residues) (unknown origin) expressed in human Jurkat cells measured after 18 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed