BDBM341178 (S)-2-(cyclopropyl((2,6-diamino-5-cyanopyrimidin-4-yl)amino)methyl)-6-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazoline-5-carbonitrile ::US9765060, Compound 8a

SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3ccc(F)c(C#N)c3c(=O)n2-c2ccccc2)n1

InChI Key InChIKey=VERYITSFWWBNJR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341178   

LigandPNGBDBM341178(US9765060, Compound 8a | (S)-2-(cyclopropyl((2,6-d...)
Affinity DataIC50: 2nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
US Patent