BDBM341230 (S)-2,4-diamino-6-((cyclopropyl(4-oxo-3-phenyl-5-(3-(piperidin-1-yl)propyl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile ::US9765060, Compound 57

SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(CCCN4CCCCC4)c3c(=O)n2-c2ccccc2)n1

InChI Key InChIKey=VKAYRALOHIVHDI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341230   

LigandPNGBDBM341230(US9765060, Compound 57 | (S)-2,4-diamino-6-((cyclo...)
Affinity DataIC50: 1.40nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
US Patent