BDBM341267 2,4-diamino-6-((2S,4R)-2-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-4-methylpyrrolidin-1-yl)pyrimidine-5-carbonitrile ::US9765060, Compound 94

SMILES C[C@@H]1C[C@H](N(C1)c1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=DCUIDXPXCJSQIC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341267   

LigandPNGBDBM341267(US9765060, Compound 94 | 2,4-diamino-6-((2S,4R)-2-...)
Affinity DataIC50: 2nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
US Patent